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Sisodia, Sangram S.

One or more keywords matched the following items that are connected to Sisodia, Sangram S.

Item Type	Name
Concept	Tumor Cells, Cultured
Concept	Cells, Cultured
Academic Article	Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Academic Article	Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Academic Article	Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
Academic Article	The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry.
Academic Article	Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
Academic Article	Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Academic Article	Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling.
Academic Article	Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Academic Article	Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
Academic Article	Lack of requirement for presenilin1 in Notch1 signaling.
Academic Article	Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
Academic Article	Effects of PS1 deficiency on membrane protein trafficking in neurons.
Academic Article	Beta-amyloid precursor protein cleavage by a membrane-bound protease.
Academic Article	Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Academic Article	Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Academic Article	Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
Academic Article	Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Academic Article	Familial British dementia: expression and metabolism of BRI.
Academic Article	Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.
Academic Article	Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules.
Academic Article	Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.
Academic Article	Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Academic Article	Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
Academic Article	Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
Academic Article	AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.
Academic Article	Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Academic Article	Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Academic Article	Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Academic Article	A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Academic Article	Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of ?-secretase using synthetic antibodies.
Academic Article	Metabolism of the amyloid precursor-like protein 2 in MDCK cells. Polarized trafficking occurs independent of the chondroitin sulfate glycosaminoglycan chain.
Academic Article	Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells.
Academic Article	Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.
Academic Article	Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Academic Article	Subcellular localization of presenilins: association with a unique membrane pool in cultured cells.
Academic Article	In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells.
Academic Article	Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.
Academic Article	Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2.
Academic Article	Differential release of ß-amyloid from dendrite- versus axon-targeted APP.
Academic Article	Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons.
Academic Article	The topology of pen-2, a ?-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.

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Cells Cultured